Charcot-Marie-Tooth disease is a group of inherited disorders that cause nerve damage. This damage is greatest in the arms and legs (peripheral nerves). Charcot-Marie-Tooth disease is also known as hereditary motor and sensory neuropathy.
Charcot-Marie-Tooth disease causes smaller and weaker muscles. You may have loss of sensation and muscle contractions, and difficulty walking. Foot deformities, such as hammertoes and high plantar arches, are also common. Symptoms usually begin in the feet and legs, but can eventually affect the hands and arms.
Symptoms of Charcot-Marie-Tooth disease usually appear in adolescence or early adulthood, but may also appear in middle age.
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Symptoms
Signs and symptoms of Charcot-Marie-Tooth disease may include the following:
Weakness in the legs, ankles, and feet.
Loss of body mass in the legs and feet
High arches of the feet
Bent toes (hammertoes)
Decreased ability to run
Difficulty flexing the heel (foot drop)
Ungainly gait or gait with knees higher than usual
Frequent trips or falls
Decreased sensation or loss of sensation in the legs and feet
As Charcot-Marie-Tooth disease progresses, symptoms may progress from the feet and legs to the hands and arms. The severity of symptoms can vary considerably from person to person, even among family members.
Causes
Charcot-Marie-Tooth disease is an inherited genetic condition. It occurs when there are mutations in the genes that affect the nerves in the feet, legs, hands, and arms.
Sometimes these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath). Both make the messages between the limbs and the brain weaker.
Risk Factors
Charcot-Marie-Tooth disease is hereditary, so you are at increased risk of developing the disorder if a member of your immediate family has had the disease.
Other causes of neuropathies, such as diabetes, can cause symptoms similar to Charcot-Marie-Tooth disease. These conditions can also cause symptoms of Charcot-Marie-Tooth disease to worsen. Medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane) and others can make symptoms worse. Be sure to tell your doctor about all the medications you take.