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ALL ABOUT SPERMATOZOIDS: Bark, Roots, Herbal Teas, Plants

By | On 26/12/2019 | Comments (0) | MALE INFERTILITY

ALL ABOUT SPERMATOZOIDS: Bark, Roots, Herbal Teas, Plants

A spermatozoon is a mobile male reproductive cell (or gamete) involved in sexual reproduction. During fertilization, the sperm unites with an egg or an oocyte (female gamete) to form an egg cell, which will then develop into an embryo to give a new individual. This is how the Dawasanté experts provide you with a natural treatment to treat your problems with sperm abnormalities (oligospermia, necrospermia, asthenospermia, teratospermia, azoospermia, etc.).

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The possible link between male infertility and chromosomal abnormalities in spermatozoa has been explored in several studies, since the advent of the technique of fluorescence in situ hybridization (FISH).

INTRODUCTION

Chromosomal abnormalities in humans may be responsible for infertility. In fact, the prevalence of abnormalities detected in the blood karyotype is ten times higher in infertile men than in the general population, ie around 5.3%, versus 0.6%. Numerical and structural abnormalities of the sex chromosomes are found with a high frequency, especially in men with severe azoospermia or oligo-astheno-teratospermia (OAT). The treatment of choice to remedy male infertility with OAT is Medically Assisted Reproduction (PMA) by  Intra Cytoplasmic Sperm Injection  (ICSI). However, it has been reported in recent years that the rate
of aneuploidy (abnormal number of chromosomes) of the sex chromosomes and de novo structural chromosomal abnormalities of paternal origin is higher in the offspring of these men. The risk of transmission of a chromosomal abnormality to offspring as the natural process of sperm selection is bypassed by the ICSI procedure should therefore be carefully considered and evaluated.

SPERMATOZOID CARYOTYPE AND FISH

Karyotypic analysis of spermatozoa makes it possible to determine in what proportion the gametes themselves are carriers of chromosomal abnormalities, in particular in infertile men.

In 1978, Rudak et al. described a technique for the karyotypic analysis of spermatozoa, based on the in vitro penetration of the latter into hamster oocytes. This technically heavy and delicate technique was only successfully practiced by a dozen laboratories around the world.

The technique of FISH (Fluorescence In Situ Hybridization) and its developments now make it possible to perform the chromosomal study of spermatozoa and analyze a large number of cells, using chromosome-specific probes that hybridize to particular regions of the DNA and can then be detected visually using a fluorescence microscope. For the FISH study, sperm from an ejaculate is spread on slides and undergo a chemical treatment resulting in the decondensation of their heads, while maintaining the structure that distinguishes them from other cells that may be in the ejaculate. Spermatozoa are also distinguished by the fact that they present signals corresponding to haploid and non-diploid cells. intact with clear hybridization signals are counted

MORPHOLOGICALLY NORMAL SPERMATOZOIDS

Morphology and motility are currently the parameters used to identify the sperm that will be microinjected as part of an ICSI procedure. Spermatozoa with an abnormal morphology are also more likely to present aneuploidy, but this risk has not been clearly quantified.

Ryu et al. studied the frequency of aneuploidy in sperm of normal morphology in infertile patients who are candidates for ICSI and all carriers of a normal blood karyotype compared to fertile patients. The morphology criterion used was that of Kruger. FISH analysis of chromosomes 18, X and Y were performed. In the group of infertile patients, and aneuploidy rate was found varying from 1.8% to 5.5% compared to 0% to 2.6% in the control patients. This result shows that the morphology of the spermatozoa is not an absolute criterion for the selection of a genetically normal spermatozoon.

Note that the different reported figures of sperm aneuploidy in men without fertility problems vary between 0 and 5% depending on the studies, differences which may be due to the use of probes with variable hybridization efficiency or to the visual interpretation of signals.

CHROMOSOMIC ANOMALIES, SPERMOGRAM AND LIFESTYLE

In a recent review, the sperm karyotypes of men without spermogram abnormalities were analyzed, with the aim of looking for possible correlations with age and lifestyle. The results of some fifty studies combining data from sperm analysis by FISH from 500 men (more than 5 million spermatozoa) were compiled. The results are an average reported rate of abnormality of 0.15% for each chromosome and 0.26% for sex chromosomes. The majority of chromosomes had an even distribution of abnormalities, with the exception of chromosomes 21, 22 and sex in which the frequencies of abnormalities were significantly higher. Trisomies 21 and 22 are also the most frequently found in the products of spontaneous miscarriages, showing the link between chromosomal abnormalities in spermatozoa and abnormalities found in the embryo. This work also demonstrated a slight increase in the frequency of disomies with paternal age, mainly for the sex chromosomes, but no effect of smoking, alcohol and caffeine consumption.

INFERTILITY AND KYOTYPES OF SPERMATOZOIDS

It is reported that 23% of men with azoospermia and 5-10% of men with OAT have an abnormal blood karyotype, resulting in a high likelihood of producing aneuploid gametes. It is known, for example, that the proportion of gametes with a chromosomal imbalance can be as high as 50% in men carrying a reciprocal translocation. However, a normal blood karyotype does not exclude the production of aneuploid gametes. An abnormal intra-testicular environment can affect spermatogenesis, in particular by disrupting the mechanisms controlling chromosome segregation during cell division.

A defect in spermatogenesis can have many origins such as systemic disease, malnutrition, endocrine disorders, obstructive pathologies and genetic defects. Indeed, a large number of severe OATs and azoospermia have genetic etiologies, including microdeletions at the level of the Y chromosome, abnormalities of meiosis, and mutations in the cystic fibrosis gene. However, “idiopathic” OAT remains the diagnosis most often retained in male infertility, despite extensive investigations to try to determine its origin. The main interest in identifying an etiology with OAT lies in the evaluation of the prognosis and the risk of producing embryos with chromosomal abnormalities.

A large study is now the source of much controversy over the relationship between spermogram abnormalities and potential risks of chromosomal abnormalities in ICSI. Fertilization and pregnancy rates obtained in relation to parameters of sperm number, mobility and morphology of infertile men were retrospectively analyzed in 966 cycles of ART with ICSI. The results showed comparable ICSI successes independent of the magnitude of OAT parameters. They concluded that in the extreme, only a living sperm in ejaculate can be sufficient for ICSI to be successful. While this study was therefore very reassuring, it does not

In order to study the etiology of “unlabelled” OATs, Calogero et al. used the FISH technique to explore the rate of aneuploidy in sperm chromosomes 8, 12, 18, X and Y in one group of patients with teratospermia, another with OAT and a control group. They observed similarly increased rates of aneuploidy in the first two groups, which suggested that teratospermia may be the critical endpoint associated with aneuploidy. The authors, therefore, recommended that a FISH analysis be performed in cases of teratospermia, before any attempt at ICSI. These same authors performed another study to try to relate the rate of sperm aneuploidy in eighteen men with OAT and the results of ICSI in affected couples. For these cases of OAT, and overall fertilization rate of 95% and a pregnancy of 39% was obtained. Very curiously, this pregnancy rate was significantly higher than reported by multiple centers practicing the ICSI technique (the generally accepted average rate is around 25%), which the authors of the article do not discuss. The rate of oocyte fertilization by ICSI was independent of the rate of aneuploidy. On the other hand, the patients who had not had a pregnancy (91%) had significantly higher aneuploidy rates than those of the controls.

Bernardini et al. also analyzed by FISH the rate of aneuploidy of the spermatozoa for chromosomes 1, 17, X, and Y, on a series of twenty-two cases of infertile men compared to fertile controls. A significantly higher rate of aneuploidy was found in men with OAT (18%) compared to controls (2.28%).

In the case of azoospermia patients, it is now sometimes possible to perform ICSI after a testicular biopsy in which sperm is found. The reported numbers of chromosomal abnormalities are impressive: indeed, one study estimated the proportion of chromosomal abnormalities at 19.6% in a group of patients with non-obstructive azoospermia and 8.2% in those with obstructive azoospermia. Here again, the link between gonadal insufficiency and the presence of chromosomal aneuploidies is well demonstrated.

It can be concluded from these data that a high rate of aneuploidy in spermatozoa is associated with a low rate of pregnancy and therefore less success through assisted reproduction by ICSI. However, the rate of fertilization of the oocytes does not seem to depend on the rate of aneuploidy, which means that the transferred embryos are more often carriers of aneuploidies and that on the other hand, their implantation would be disadvantaged. In this context, genetic counseling following a FISH analysis of the sperm would be highly desirable, before a couple begins a long and difficult procedure of assisted reproduction by ICSI.

SPERMATOZOID ANEUPLOIDS AND GENE FACTORS

A particularly important point of these studies is that they make it possible to explain certain male infertilities so far called “idiopathic”. In fact, disturbances of meiosis or premeiotic mitosis during spermatogenesis could predispose to the non-chromosomal disjunctions that are observed. The next step would consist in identifying which are the genetic factors at the origin of these disorders of meiosis and mitosis and to characterize them to have one more diagnostic means available in idiopathic male infertility. If gene abnormalities predisposing to non-disjunctions were detected, this diagnostic tool would be available and the possible transmission in the offspring of this pathology would be evaluable. And then supported by numerous studies. We now know that at least thirty genes are involved in the control of meiotic and mitotic divisions. For example, the role of HspA2, a “chaperone” protein with a specific testicular expression that is thought to be involved in the synaptonemal complex has recently been demonstrated. The role of genes of the MAD (Mitotic Arrest Deficiency) family involved in premeiotic mitotic control is also discussed.

There is a case, recently reported in the literature, where FISH analysis of spermatozoa made it possible to pose a contraindication to ART. In the study in question patients with different types of absolute teratospermia (100%) were studied. One of them had a sperm morphological abnormality consisting of macrocephaly and multiple flagella. In this patient, 90% of the sperm analyzed by FISH presented aneuploidy. This result was considered to be a contraindication to ICSI.

FEASIBILITY

In these various studies, between 3000 and 10,000 sperm per patient are analyzed. This represents a significant investment of time, considering that for FISH analysis on amniocytes, there are routinely between 50 and 100 cells. It is estimated that to detect significant levels of aneuploidy in sperm, an analysis of around 1000 cells may be sufficient. The method of collection is no different from that for a spermogram, and only a small fraction of ejaculate is used to smear onto slides for chemical treatment of the sample prior to FISH.

CONCLUSION

While the use of FISH on spermatozoa in male infertility appears undoubtedly valuable and contributory in the context of a pre-ART workup, or after repeated ART failures, the formal indications for this analysis have not yet been clearly established. established. One of the first uses of this approach could be to give couples undergoing a pre-ICSI procedure for OAT or azoospermia a more detailed indication of the chances of success and risks of miscarriages due to chromosomal abnormalities potentially present in the sperm. This information should then be communicated to patients within the framework of genetic counseling, taking into account the psychological repercussions of a possible poor prognosis of success.

Some authors also consider that this technique can be used in the event of miscarriages with repetitions of undetermined etiology beyond the framework of male infertility. Indeed, if 60% of the miscarriages of the first trimester are due to chromosomal abnormalities and a majority are of maternal origin, the FISH technique on the spermatozoa has shown a paternal origin in 8 to 12% of cases, corresponding to a greater incidence of chromosomal abnormalities in their gametes.

 

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Remède naturel par les plantes pour soigner l’infertilité féminine. Nous avons de la représentation dans tous les pays d’Afrique et activement dans les pays suivant: Cameroun, Côte d’ivoire, Mali, Sénégal, Burkina Faso, Togo, Kenya, Nigeria, Gabon, République centrafricaine, Bénin, Tchad, Congo Brazzaville et Kinshasa. Soyez donc rassuré que vous recevrez vos produits immédiatement après votre commande. La livraison est gratuite. Livraison gratuite partout dans le monde Vous pouvez nous contacter par whatsapp au: +229 51374202Remède naturel par les plantes pour soigner l'infertilité féminine Vous êtes en couple avec votre conjoint depuis un moment, et ça y est, c’est le moment de fonder une famille. Mais après 1 an de rapport sexuel régulier non protégé, toujours pas de grossesse. Alors, vous souffrez peut-être d’infertilité féminine. Premièrement, il est important de définir, mais aussi de comprendre pourquoi il y a infertilité. Mais la recherche des causes d'infertilité doit se faire parallèlement chez les deux partenaires. Enfin, ce n'est qu'au terme de ces investigations que l'infertilité de l'un ou de l'autre peut être établie et que l’on pourra commencer le traitement. L’infertilité féminine peut être causée par de nombreux troubles ou dysfonctionnements gynécologiques : endométriose, anovulation (absence d’ovulation), polypes utérins, fibromes utérins, fausses couches, trompes bouchées, obésité, kystes ovariens, stress, consommation excessive d'alcool... Pour chacune des causes d’infertilité féminine citée ci-dessus, nous vous proposons un traitement naturel spécifique. Il s'agit du secret pour guérir l’infertilité féminine. Néanmoins, il est indispensable que vous consulté un gynécologue ou que vous ayez subi un bilan de fertilité pour connaitre la cause principale de votre infertilité. Notre prise en charge en cas d’infertilité féminine dépend de l’origine du mal. La composition du remède naturel dépendra donc de la cause de l’infertilité féminine. Nos traitements naturels sont uniquement faits à base de plantes dont l’efficacité est scientifiquement prouvée. Ainsi c’est le meilleur Remède naturel contre l'infertilité féminine fait avec des plantes médicinales. Ils sont la solution miracle pour guérir pratiquement toutes les formes d’infertilité féminine. Après consultation gynécologiques, si vous souffrez : -des trompes de Fallope bouchées, cliquez sur ce lien -d’une absence d’ovulation (anovulation), cliquez sur ce lien -d’endométriose, cliquez sur ce lien -de fibromes, cliquez sur ce lien -de kystes ovariens (syndrome des ovaires polykystiques), cliquez sur ce lien -de polypes utérins, cliquez sur ce lien -de fausses couches répétitives, cliquez sur ce lien Cependant, vous pouvez souffrir de l’une ou de plusieurs de ces causes à la fois. Mais soyez sans crainte, nos traitements naturels ont déjà faits la preuve de leur efficacité dans chacun des causes d’infertilité féminine énumérées ci-dessus. Les plantes que nous utilisons sont alors la solution parfaite pour guérir d’infertilité féminine. Elles entrent même dans la composition de certains médicaments. Nos remèdes naturels sont le secret pour guérir toute forme d’infertilité féminine. Nous vous offrons un avantage certain : l’absence d’effets indésirables et de contre-indications. L’approche naturelle est souvent la meilleure approche à adopter pour trouver la solution. Nos remèdes naturels ont permis à de très nombreuses femmes d’avoir des enfants. Étant des produits naturels à base de plantes et d’herbes, nos remèdes naturels n’entrainent aucun effet secondaire, que ce soit sur l’organisme ou sur la santé. Notre traitement naturel n’est pas dangereux. Vous pourrez donc guérir d’infertilité féminine sans craindre l’apparition d’effets secondaires. Aussi, il est important que vous soyez patiente. Même pour une femme ne souffrant d’aucun problème de fertilité, concevoir un enfant peut naturellement prendre du temps. NB : À l'inverse d'une idée préconçue encore trop répandue, la femme n'est pas l’unique responsable quand un couple n’arrive pas à avoir un enfant. L’homme souffre d’infertilité masculine dans près de 50% des cas. Par exemple, une femme peut avoir des fibromes et son partenaire peut avoir une faible numération des spermatozoïdes (oligospermie). Demander donc à votre homme de faire un spermogramme. Cela nous permettra de connaitre avec exactitude la source du problème.  Durée du traitement  La durée du traitement naturel dépendra avant tout de la cause de l’infertilité féminine. Elle varie généralement de 1 à 2 mois. Mais soyez sans crainte, nos remèdes naturels sont la solution pour guérir la quasi-totalité des cas d’infertilité féminine. Toutefois, notre prise en charge est individualisée. Elle variera alors en fonction de la cause de l’infertilité féminine et de vos attentes.   Nous avons de la représentation dans tous les pays d’Afrique et activement dans les pays suivant: Cameroun, Côte d’ivoire, Mali, Sénégal, Burkina Faso, Togo, Kenya, Nigeria, Gabon, République centrafricaine, Bénin, Tchad, Congo Brazzaville et Kinshasa. Soyez donc rassuré que vous recevrez vos produits immédiatement après votre commande. La livraison est gratuite. Livraison gratuite partout dans le monde Vous pouvez nous contacter par whatsapp au: +229 51374202 Pour contacter nos experts veuillez appeler ou nous écrire sur le numéro suivant, tel/WhatsApp :0022951374202 Nos conseils pour booster la fertilité chez la femme   -Éviter l’alcool, la caféine et le tabac Un mode de vie saine est la base pour concevoir un bébé. Sachez que même une consommation modérée peut augmenter les taux de prolactine et empêcher l’ovulation. Toutefois, fumer et boire de l’alcool ne contribuent certainement pas à booster la fertilité. Ainsi, l’infertilité féminine est aussi liée au tabagisme. Non seulement il diminue la fertilité, mais il peut aussi accélérer la ménopause. Les femmes qui consomment une tasse de café par jour ont donc deux fois moins de chances de concevoir.   -Réduisez votre stress C’est l’un des facteurs les plus importants. Nous vous conseillons la pratique des techniques de relaxation telles que le yoga, l’acupuncture et la méditation. Discuter aussi le plus souvent possible avec votre partenaire. Vous aurez besoin du soutien moral de votre entourage. Éviter le stress, car il est mauvais pour la grossesse.   -Maintenir un poids santé Être en sous-poids ou en surpoids peut affecter les niveaux d’hormones du corps, ce qui augmente la difficulté à concevoir. Ainsi, lorsque vous êtes en sous-poids (anorexie) vous devez reprendre un peu de poids pour permettre à votre organisme de remettre en route votre système reproducteur. À l'inverse, une femme en surpoids devra perdre du poids en contrôlant son alimentation et/ou en menant une activité physique.   -Surveillez votre température basale de votre corps Cela vous aidera à déterminer le moment le plus probable de l’ovulation pour planifier vos rapports sexuels. Ainsi, lorsqu’elle est de 37 degrés, vous êtes probablement en période ovulatoire. C’est le bon moment.   -Éviter la consommation de produits laitiers non pasteurisés Nous vous conseillons les aliments suivants : les épinards, le melon, les salades, le saumon, les anchois, les céréales, les légumes secs, les fruits et tout ce qui est à base de fibre. -Une alimentation riche en magnésium et en vitamine B6, car ils sont nécessaires pour la production de la progestérone (l’hormone de gestation). Vous trouverez les deux en quantité suffisante dans jaune d'œuf, les légumineuses, les légumes verts et les noix et graines. -Manger les aliments riches en vitamine C, car ils aident à renforcer la paroi de l’utérus. On trouve la vitamine C généralement dans les fruits (oranges, pamplemousse, citron, etc.). -Consommer les aliments riches en acides gras oméga-3 comme les avocats, les poissons, l’huile de coco   Nous avons de la représentation dans tous les pays d’Afrique et activement dans les pays suivant: Cameroun, Côte d’ivoire, Mali, Sénégal, Burkina Faso, Togo, Kenya, Nigeria, Gabon, République centrafricaine, Bénin, Tchad, Congo Brazzaville et Kinshasa. Soyez donc rassuré que vous recevrez vos produits immédiatement après votre commande. La livraison est gratuite. Livraison gratuite partout dans le monde Vous pouvez nous contacter par whatsapp au: +229 51374202 Pour contacter nos experts veuillez appeler ou nous écrire sur le numéro suivant, tel/WhatsApp :0022951374202   NOUS LIVRONS PARTOUT DANS LE MONDE  

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Traitements et remedes par les plantes dafrique bio naturels jambes lourdes dawabio 600x400
VENOUS INSUFFICIENCY/ HEAVY LEGS: herbal tea and balm

€300.0 inc. tax

natural remedy to cure hepatitis b
Hepatitis b and c: Herbal Tea and Plant

€300.0 inc. tax

Prosta
HERBAL TEA FOR HYPOTENSION

€350.0 inc. tax

Traitement naturel par les plantes bio remede simple tisane hernie discal arthrose sciatique dawabio 1
Jatropha curcas and cassava extracts against HIV / AIDS

€200.0 inc. tax

Urinary incontinence
STOP PIPI IN BED (enuresis) and URINARY INCONTINENCE

€150.0 inc. tax

Traitement remede par les plantes naturel contre infertilite masculine 600x400 2
PROLAPSE: Herbal tea, Plant, Root, Bark

€300.0 inc. tax

Traitement remede par les plantes naturel contre infertilite masculine 600x400 2
CANCER OF THE BREAST: Herbal tea, Roots, Plants, Bark

€300.0 inc. tax

LES PLANTES CONTRE LA TERATOSPERMIE
TERATOSPERMIA : Barks, Roots, Herbal Teas, Plants

€350.0 inc. tax

Plante medicinale pour lasthme dawabio com 600x400 1
HYPERTENSION: Plants, Herbal teas, Roots, Barks

€300.0 inc. tax

Remedes traitement naturel par les plantes maladie de parkinson dawabio com
DIABETES: Remedy, Herbal teas, Plants, Roots

€400.0 inc. tax

OTHER FEMALE PATHOLOGIES

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  • 2005
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  • Abdoul86
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